SOSTIENICI
Pubblicazioni recenti - cardiac disease
-
Access to Left Ventricular Assist Device: Travel Time Does Not Tell The Whole Story.
J Surg Res2021 Nov;271():52-58. doi: S0022-4804(21)00688-0.
Mehaffey J Hunter, Cullen J Michael, Hawkins Robert B, Fonner Clifford, Kern John, Speir Alan, Quader Mohammed, Ailawadi Gorav, Teman Nicholas, Yarboro Leora,
Abstract
BACKGROUND:
Negative health effects of traveling longer distances for surgical services have been reported. Given the high complexity of multidisciplinary care required for management of Left Ventricular Assist Device (LVAD) implantation, only 4 of 18 centers in our state perform these operations. Given the limited access we hypothesized increased travel time would adversely affect postoperative outcomes and 30-d mortality.
METHODS:
A statewide Society of Thoracic Surgeons database was queried to identify patients undergoing Heartmate II/III and HVAD implantation, and 725 patients were identified. Travel time was calculated by zip code. Patients were stratified into regional and distant groups by the upper quartile of travel time (1-h). Preoperative variables and outcomes were compared between the groups. Multivariate analysis was performed to evaluate the impact of travel time in risk-adjusted models of 30-d mortality.
RESULTS:
Median patient travel time to their LVAD center in our state is 32 min (mean 53 ± 65 min, 46 ± 71 miles). Patients in the distant group (n = 191) had lower median incomes, higher self-pay status, higher rates of medical comorbid disease. Despite these differences there was no difference between the groups in ICU and/or hospital length of stay, readmission, postoperative complications, or 30-d mortality. Multivariate regression demonstrated insurance status, age, and prior surgery predicted 30-d mortality, but not travel time.
CONCLUSIONS:
Despite only four centers in the state performing LVAD implantation, travel time was strongly associated with preoperative risk, and socioeconomic status but not postoperative outcomes or 30-d mortality. Therefore, increasing access should focus on insurance, and patient characteristics not travel time.
Copyright © 2021. Published by Elsevier Inc.
Guarda su PubMed
-
Correction to: Off-label-dosing of non-vitamin K-dependent oral antagonists in AF patients before and after stroke: results of the prospective multicenter Berlin Atrial Fibrillation Registry.
J Neurol2021 Nov;():. doi: 10.1007/s00415-021-10907-w.
Tütüncü Serdar, Olma Manuel, Kunze Claudia, Dietzel Joanna, Schurig Johannes, Fiessler Cornelia, Malsch Carolin, Haas Tobias Eberhard, Dimitrijeski Boris, Doehner Wolfram, Hagemann Georg, Hamilton Frank, Honermann Martin, Jungehulsing Gerhard Jan, Kauert Andreas, Koennecke Hans-Christian, Mackert Bruno-Marcel, Nabavi Darius, Nolte Christian H, Reis Joschua Mirko, Schmehl Ingo, Sparenberg Paul, Stingele Robert, Völzke Enrico, Waldschmidt Carolin, Zeise-Wehry Daniel, Heuschmann Peter U, Endres Matthias, Haeusler Karl Georg,
Guarda su PubMed
-
Whipple's disease in renal transplant recipients: Management experience of 7 cases from Pakistan.
Transpl Infect Dis2021 Nov;():. doi: 10.1111/tid.13769.
Nasim Asma, Dodani Sunil Kumar, Badlani Sanjay, Babar Zaheer Udin, Shakil Shaheera, Mubarak Mohammad, Luck Nasir, Aziz Tahir,
Abstract
INTRODUCTION:
Whipple's disease (WD) is a rare multi-systemic disorder caused by actinomycetes, Tropheryma Whipplei (T. Whipplei). It presents with weight loss, arthralgia and diarrhea and may involve the heart, lung or central nervous system. The use of immunosuppressive medications or underlying immunodeficiency states are associated risk factors. Six cases in transplant recipients have so far been reported worldwide. We describe our experience of Whipple's disease in renal transplant recipients.
METHODS:
All renal transplant recipients who presented with diarrhea and were diagnosed with Whipple's disease on duodenal biopsy from 2016 till 2019 were included. Their data regarding duration since transplantation, immunosuppressive therapy, symptoms, treatment response and outcome was analyzed.
RESULTS:
Seven cases were diagnosed as Whipple's disease based on duodenal biopsy, with histological findings of Periodic acid Schiff positive granules in macrophages. All were male. The most common symptoms were chronic diarrhea and weight loss. Average time since transplantation was 4.8 years. All patients were on azathioprine and everolimus. Clinical relapse or adverse effects was seen in 5 of 7 patients treated with doxycycline and hydroxychloroquine which was discontinued. Trimethoprim/sulphamethoxazole for one year, with initial intravenous ceftriaxone in 2 patients, resulted in complete remission in all patients at a follow-up period averaging 1.5 years.
CONCLUSION:
Whipple's diseases in renal transplant recipients most commonly presents as an intestinal disorder. Treatment of one year with Trimethoprim/sulphamethoxazole has good response with complete remission at 1.5 years of follow up. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
Guarda su PubMed
-
Opioid use is associated with increased out-of-hospital cardiac arrest risk among 40,000-cases across two countries.
Br J Clin Pharmacol2021 Nov;():. doi: 10.1111/bcp.15157.
Eroglu Talip E, Barcella Carlo A, Blom Marieke T, Souverein Patrick C, Mohr Grimur H, Torp-Pedersen Christian, Folke Fredrik, Wissenberg Mads, de Boer Anthonius, Gislason Gunnar H, Tan Hanno L, ,
Abstract
AIM:
Opioid use has substantially increased in the last decade and is associated with overdose mortality, but also with increased mortality from cardiovascular causes. This finding may partly reflect an association between opioids and out-of-hospital cardiac arrest (OHCA). Therefore, we aimed to investigate OHCA-risk of opioids in the community.
METHODS:
We conducted two population-based case-control studies separately in the Netherlands (2009-2018) and Denmark (2001-2015). Cases were individuals who experienced OHCA of presumed cardiac cause. Each case was matched with up to five non-OHCA-controls according to age, sex and OHCA-date. Conditional logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI).
RESULTS:
We included 5,473 OHCA-cases matched with 21,866 non-OHCA-controls in the Netherlands, and 35,017 OHCA-cases matched with 175,085 non-OHCA-controls in Denmark. We found that use of opioids (the Netherlands: cases: 5.4%, controls: 1.8%; Denmark: cases: 11.9%, controls: 4.4%) was associated with increased OHCA-risk in both regions (the Netherlands: OR 2.1 [95%-CI 1.8-2.5]; Denmark: OR 1.8 [95%-CI 1.5-2.1]). The association was observed in both sexes, and in individuals with cardiovascular disease (the Netherlands: OR 1.8 [95%-CI 1.5-2.1]; Denmark: OR 1.6 [95%-CI 1.5-1.7]) or without (the Netherlands: OR 3.4 [95%-CI: 2.4-4.8], P-interaction
CONCLUSION:
Use of opioids is associated with increased OHCA-risk in both sexes, independently of concomitant cardiovascular disease. These findings should be considered when evaluating the harms and benefits of treatment with opioids.
This article is protected by copyright. All rights reserved.
Guarda su PubMed
-
Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation.
Br J Pharmacol2021 Nov;():. doi: 10.1111/bph.15757.
TeBay Clifford, McArthur Jeffrey R, Mangala Melissa, Kerr Nicholas, Heitmann Stewart, Perry Matthew D, Windley Monique J, Vandenberg Jamie I, Hill Adam P,
Abstract
BACKGROUND AND PURPOSE:
Hydroxychloroquine, chloroquine and azithromycin are three drugs that were proposed to treat COVID-19. While concern already existed around their proarrhythmic potential there is little data regarding how altered physiological states encountered in patients such as febrile state, electrolyte imbalances or acidosis might change their risk profiles.
EXPERIMENTAL APPROACH:
Potency of hERG block was measured using high-throughput electrophysiology in the presence of variable environmental factors. These potencies informed simulations to predict population risk profiles. Effects on cardiac repolarisation were verified in human induced pluripotent stem cell-derived cardiomyocytes from multiple individuals.
KEY RESULTS:
Chloroquine and hydroxychloroquine blocked hERG with IC of 1.47±0.07 ?M and 3.78±0.17 ?M respectively, indicating proarrhythmic risk at concentrations effective against SARS-CoV-2 in vitro. Hypokalaemia and hypermagnesemia increased potency of chloroquine and hydroxychloroquine, indicating increased proarrhythmic risk. Acidosis significantly reduced potency of all drugs, whereas increased temperature decreased potency of chloroquine and hydroxychloroquine against hERG but increased potency for azithromycin. In silico simulations demonstrated that proarrhythmic risk was increased by female sex, hypokalaemia and heart failure, and identified specific genetic backgrounds associated with emergence of arrhythmia.
CONCLUSION AND IMPLICATIONS:
Our study demonstrates how proarrhythmic risk can be exacerbated by metabolic changes and pre-existing disease. More broadly, the study acts as a blueprint for how high-throughput in vitro screening, combined with in silico simulations can help guide both preclinical screening and clinical management of patients in relation to drugs with potential to prolong repolarisation.
This article is protected by copyright. All rights reserved.
Guarda su PubMed
-
Housing Instability and Socioeconomic Disparities in Health: Evidence from the U.S. Economic Recession.
J Racial Ethn Health Disparities2021 Nov;():. doi: 10.1007/s40615-021-01181-7.
Wang Kyungsoon,
Abstract
While a number of studies have observed the effects of housing instability on health outcomes, fewer have emphasized pre-existing socioeconomic disparities in health and the influence of housing instability on subsequent health outcomes in the wake of the economic recession. Using national data on six adult health indictors and foreclosure data aggregated by census tract, this study examines the association between neighborhood housing insecurity and health outcomes, particularly focusing on various income levels and racial groups in about 200 U.S. metropolitan areas after the 2008 housing crisis. Results suggest that high levels of housing instability induced by high levels of foreclosed properties in certain neighborhoods were strongly associated with more health problems among residents, but the results varied according to the income level and the dominant racial group in these neighborhoods. With regard to income levels, adverse health conditions in lower income neighborhoods remained longer and became stronger than those in higher income neighborhoods. The findings also show variation among racial groups: While multiple health problems plagued all income levels in white tracts, more severe and worsening pre-existing health problems appeared in lower income minority tracts. In addition, neighborhood housing instability generated by mortgage foreclosures was strongly associated with heart-related diseases, particularly in middle-income White neighborhoods, and mental health problems, particularly in upper-income Hispanic tracts. Finally, among multiple health indicators, mental health problems were the most common health conditions during the U.S. economic recession. In light of the socioeconomic disparities in health, policy makers should establish effective policy tools that integrate health and urban and housing planning.
© 2021. W. Montague Cobb-NMA Health Institute.
Guarda su PubMed
-
Deep learning enables genetic analysis of the human thoracic aorta.
Nat Genet2021 Nov;():. doi: 10.1038/s41588-021-00962-4.
Pirruccello James P, Chaffin Mark D, Chou Elizabeth L, Fleming Stephen J, Lin Honghuang, Nekoui Mahan, Khurshid Shaan, Friedman Samuel F, Bick Alexander G, Arduini Alessandro, Weng Lu-Chen, Choi Seung Hoan, Akkad Amer-Denis, Batra Puneet, Tucker Nathan R, Hall Amelia W, Roselli Carolina, Benjamin Emelia J, Vellarikkal Shamsudheen K, Gupta Rajat M, Stegmann Christian M, Juric Dejan, Stone James R, Vasan Ramachandran S, Ho Jennifer E, Hoffmann Udo, Lubitz Steven A, Philippakis Anthony A, Lindsay Mark E, Ellinor Patrick T,
Abstract
Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions of the ascending and descending thoracic aorta in 4.6 million cardiac magnetic resonance images from the UK Biobank. We then conducted genome-wide association studies in 39,688 individuals, identifying 82 loci associated with ascending and 47 with descending thoracic aortic diameter, of which 14 loci overlapped. Transcriptome-wide analyses, rare-variant burden tests and human aortic single nucleus RNA sequencing prioritized genes including SVIL, which was strongly associated with descending aortic diameter. A polygenic score for ascending aortic diameter was associated with thoracic aortic aneurysm in 385,621 UK Biobank participants (hazard ratio = 1.43 per s.d., confidence interval 1.32-1.54, P = 3.3 × 10). Our results illustrate the potential for rapidly defining quantitative traits with deep learning, an approach that can be broadly applied to biomedical images.
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.
Guarda su PubMed
-
ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1.
Exp Mol Med2021 Nov;():. doi: 10.1038/s12276-021-00701-z.
Sonn Seong Keun, Seo Seungwoon, Yang Jaemoon, Oh Ki Sook, Chen Hsiuchen, Chan David C, Rhee Kunsoo, Lee Kyung S, Yang Young, Oh Goo Taeg,
Abstract
C1q/TNF-related protein 1 (CTRP1) is a CTRP family member that has collagenous and globular C1q-like domains. The secreted form of CTRP1 is known to be associated with cardiovascular and metabolic diseases, but its cellular roles have not yet been elucidated. Here, we showed that cytosolic CTRP1 localizes to the endoplasmic reticulum (ER) membrane and that knockout or depletion of CTRP1 leads to mitochondrial fission defects, as demonstrated by mitochondrial elongation. Mitochondrial fission events are known to occur through an interaction between mitochondria and the ER, but we do not know whether the ER and/or its associated proteins participate directly in the entire mitochondrial fission event. Interestingly, we herein showed that ablation of CTRP1 suppresses the recruitment of DRP1 to mitochondria and provided evidence suggesting that the ER-mitochondrion interaction is required for the proper regulation of mitochondrial morphology. We further report that CTRP1 inactivation-induced mitochondrial fission defects induce apoptotic resistance and neuronal degeneration, which are also associated with ablation of DRP1. These results demonstrate for the first time that cytosolic CTRP1 is an ER transmembrane protein that acts as a key regulator of mitochondrial fission, providing new insight into the etiology of metabolic and neurodegenerative disorders.
© 2021. The Author(s).
Guarda su PubMed
-
Direct pixel to pixel principal strain mapping from tagging MRI using end to end deep convolutional neural network (DeepStrain).
Sci Rep2021 Nov;11(1):23021. doi: 10.1038/s41598-021-02279-y.
Abd-Elmoniem Khaled Z, Yassine Inas A, Metwalli Nader S, Hamimi Ahmed, Ouwerkerk Ronald, Matta Jatin R, Wessel Mia, Solomon Michael A, Elinoff Jason M, Ghanem Ahmed M, Gharib Ahmed M,
Abstract
Regional soft tissue mechanical strain offers crucial insights into tissue's mechanical function and vital indicators for different related disorders. Tagging magnetic resonance imaging (tMRI) has been the standard method for assessing the mechanical characteristics of organs such as the heart, the liver, and the brain. However, constructing accurate artifact-free pixelwise strain maps at the native resolution of the tagged images has for decades been a challenging unsolved task. In this work, we developed an end-to-end deep-learning framework for pixel-to-pixel mapping of the two-dimensional Eulerian principal strains [Formula: see text] and [Formula: see text] directly from 1-1 spatial modulation of magnetization (SPAMM) tMRI at native image resolution using convolutional neural network (CNN). Four different deep learning conditional generative adversarial network (cGAN) approaches were examined. Validations were performed using Monte Carlo computational model simulations, and in-vivo datasets, and compared to the harmonic phase (HARP) method, a conventional and validated method for tMRI analysis, with six different filter settings. Principal strain maps of Monte Carlo tMRI simulations with various anatomical, functional, and imaging parameters demonstrate artifact-free solid agreements with the corresponding ground-truth maps. Correlations with the ground-truth strain maps were R?=?0.90 and 0.92 for the best-proposed cGAN approach compared to R?=?0.12 and 0.73 for the best HARP method for [Formula: see text] and [Formula: see text], respectively. The proposed cGAN approach's error was substantially lower than the error in the best HARP method at all strain ranges. In-vivo results are presented for both healthy subjects and patients with cardiac conditions (Pulmonary Hypertension). Strain maps, obtained directly from their corresponding tagged MR images, depict for the first time anatomical, functional, and temporal details at pixelwise native high resolution with unprecedented clarity. This work demonstrates the feasibility of using the deep learning cGAN for direct myocardial and liver Eulerian strain mapping from tMRI at native image resolution with minimal artifacts.
© 2021. The Author(s).
Guarda su PubMed
-
Management of ischaemia with non-obstructive coronary arteries (INOCA).
BMJ2021 Nov;375():e060602. doi: 10.1136/bmj-2021-060602.
Beltrame John F, Tavella Rosanna, Jones Dione, Zeitz Chris,
Abstract
Up to half of patients undergoing elective coronary angiography for the investigation of chest pain do not present with evidence of obstructive coronary artery disease. These patients are often discharged with a diagnosis of non-cardiac chest pain, yet many could have an ischaemic basis for their symptoms. This type of ischaemic chest pain in the absence of obstructive coronary artery disease is referred to as INOCA (ischaemia with non-obstructive coronary arteries). This comprehensive review of INOCA management looks at why these patients require treatment, who requires treatment based on diagnostic evaluation, what clinical treatment targets should be considered, how to treat patients using a personalised medicine approach, when to initiate treatment, and where future research is progressing.
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Guarda su PubMed
-
Indications and outcome after lung transplantation in children under 12 years of age: A 16-year single center experience.
J Heart Lung Transplant2021 Oct;():. doi: S1053-2498(21)02571-7.
Iablonskii Pavel, Carlens Julia, Mueller Carsten, Aburahma Khalil, Niehaus Adelheid, Boethig Dietmar, Franz Maximilian, Floethmann Katharina, Sommer Wiebke, Optenhoefel Joerg, Tudorache Igor, Greer Mark, Koeditz Harald, Jack Thomas, Hansmann Georg, Kuehn Christian, Horke Alexander, Hansen Gesine, Haverich Axel, Warnecke Gregor, Avsar Murat, Salman Jawad, Bobylev Dmitry, Ius Fabio, Schwerk Nicolaus,
Abstract
OBJECTIVE:
Paediatric lung transplantation poses unique management challenges. Experience regarding indications and outcome is scarce, especially in younger children. The primary aim of this study was to investigate outcome after first lung transplantation in children
METHODS:
Records of patients
RESULTS:
Of the 117 patients underwent first lung transplantation at our institution, of whom 42 (35.8%) patients were
CONCLUSIONS:
Lung transplantation in children under 12 years is challenging due to underlying medical conditions and operative complexity. Nevertheless, outcomes are comparable to those in older children.
Copyright © 2021 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
Guarda su PubMed
-
Chronic thromboembolic pulmonary hypertension in patients with antiphospholipid syndrome: Risk factors and management.
J Heart Lung Transplant2021 Oct;():. doi: S1053-2498(21)02569-9.
Rosen Keren, Raanani Ehud, Kogan Alexander, Kenet Gili, Misgav Mudi, Lubetsky Aharon, Niznik Stanely, Schäfers Hans-Joachim, Segel Michael J, Agmon-Levin Nancy,
Abstract
BACKGROUND:
Antiphospholipid syndrome (APS) may cause chronic thromboembolic pulmonary hypertension (CTEPH). Current knowledge regarding prevalence and risk factors for CTEPH among APS patients is limited. We sought to determine clinical features and biomarkers that could identify APS subjects suffering from CTEPH, and describe the prevalence, course and treatment outcomes of patients with APS-CTEPH.
METHODS:
504 APS patients were treated in our center during 2008 to 2019. We studied clinical and laboratory features of 69 APS patients, comparing 19 patients diagnosed with CTEPH (APS-CTEPH) and treated accordingly, with 50 consecutive age and gender matched patients with no evidence of pulmonary hypertension (APS-No-CTEPH).
RESULTS:
CTEPH prevalence was 3.8% in our APS cohort and was linked with the following parameters: primary APS (p
CONCLUSIONS:
CTEPH is relatively common in APS. Primary APS, prior PE, recurrent VTE, thrombocytopenia and specific anti-phospholipid antibodies predict CTEPH in APS. Active assessment for CTEPH in APS patients should be considered, as PEA was found to be effective and relatively safe, especially if electively performed.
Copyright © 2021 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
Guarda su PubMed
-
[Retinal vascular network: Changes with aging and systemic vascular disease (cardiac and cerebral)].
J Fr Ophtalmol2021 Nov;():. doi: S0181-5512(21)00521-0.
Arnould L, Guenancia C, Binquet C, Delcourt C, Chiquet C, Daien V, Cottin Y, Bron A M, Acar N, Creuzot-Garcher C,
Abstract
For over 10 years, the description of the retinal microvascular network has benefited from the development of new imaging techniques. Automated retinal image analysis software, as well as OCT angiography (OCT-A), are able to highlight subtle, early changes in the retinal vascular network thanks to a large amount of microvascular quantitative data. The challenge of current research is to demonstrate the association between these microvascular changes, the systemic vascular aging process, and cerebrovascular and cardiovascular disease. Indeed, a pathophysiological continuum exists between retinal microvascular changes and systemic vascular diseases. In the Montrachet study, we found that a suboptimal retinal vascular network, as identified by the Singapore I Vessel Assessment (SIVA) software, was significantly associated with treated diabetes and an increased risk of cardiovascular mortality. In addition, we supplemented our research on the retinal vascular network with the use of OCT-A. In the EYE-MI study, we showed the potential role of quantitative characterization of the retinal microvascular network by OCT-A in order to assess the cardiovascular risk profile of patients with a history of myocardial infarction. A high AHA (American Heart Association) risk score was associated with low retinal vascular density independently of hemodynamic changes. Thus, a better understanding of the association between the retinal microvasculature and macrovascular disease might make its use conceivable for early identification of at-risk patients and to suggest a personalized program of preventative care. The retinal vascular network could therefore represent an indicator of systemic vascular disease as well as an interesting predictive biomarker for vascular events.
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
Guarda su PubMed
-
Native-resolution myocardial principal Eulerian strain mapping using convolutional neural networks and Tagged Magnetic Resonance Imaging.
Comput Biol Med2021 Nov;():105041. doi: S0010-4825(21)00835-0.
Yassine Inas A, Ghanem Ahmed M, Metwalli Nader S, Hamimi Ahmed, Ouwerkerk Ronald, Matta Jatin R, Solomon Michael A, Elinoff Jason M, Gharib Ahmed M, Abd-Elmoniem Khaled Z,
Abstract
BACKGROUND:
Assessment of regional myocardial function at native pixel-level resolution can play a crucial role in recognizing the early signs of the decline in regional myocardial function. Extensive data processing in existing techniques limits the effective resolution and accuracy of the generated strain maps. The purpose of this study is to compute myocardial principal strain maps ? and ? from tagged MRI (tMRI) at the native image resolution using deep-learning local patch convolutional neural network (CNN) models (DeepStrain).
METHODS:
For network training, validation, and testing, realistic tMRI datasets were generated and consisted of 53,606 cine images simulating the heart, the liver, blood pool, and backgrounds, including ranges of shapes, positions, motion patterns, noise, and strain. In addition, 102 in-vivo image datasets from three healthy subjects, and three Pulmonary Arterial Hypertension patients, were acquired and used to assess the network's in-vivo performance. Four convolutional neural networks were trained for mapping input tagging patterns to corresponding ground-truth principal strains using different cost functions. Strain maps using harmonic phase analysis (HARP) were obtained with various spectral filtering settings for comparison. CNN and HARP strain maps were compared at the pixel level versus the ground-truth and versus the least-loss in-vivo maps using Pearson correlation coefficients (R) and the median error and Inter-Quartile Range (IQR) histograms.
RESULTS:
CNN-based local patch DeepStrain maps at a phantom resolution of 1.1mm × 1.1 mm and in-vivo resolution of 2.1mm × 1.6 mm were artifact-free with multiple fold improvement with ? ground-truth median error of 0.009(0.007) vs. 0.32(0.385) using HARP and ? ground-truth error of 0.016(0.021) vs. 0.181(0.08) using HARP. CNN-based strain maps showed substantially higher agreement with the ground-truth maps with correlation coefficients R > 0.91 for ? and ? compared to R
CONCLUSION:
CNN-generated Eulerian strain mapping permits artifact-free visualization of myocardial function at the native image resolution.
Copyright © 2021. Published by Elsevier Ltd.
Guarda su PubMed
-
Association between Dietary Pattern and Periodontitis-A Cross-Sectional Study.
Nutrients2021 Nov;13(11):. doi: 4167.
Altun Ersin, Walther Carolin, Borof Katrin, Petersen Elina, Lieske Berit, Kasapoudis Dimitros, Jalilvand Navid, Beikler Thomas, Jagemann Bettina, Zyriax Birgit-Christiane, Aarabi Ghazal,
Abstract
The aim of the study was to investigate the relationship between specific known dietary patterns and the prevalence of periodontal disease in a northern population-based cohort study. We evaluated data from 6209 participants of the Hamburg City Health Study (HCHS). The HCHS is a prospective cohort study and is registered at ClinicalTrial.gov (NCT03934957). Dietary intake was assessed with the food frequency questionnaire (FFQ2). Periodontal examination included probing depth, gingival recession, plaque index, and bleeding on probing. Descriptive analyses were stratified by periodontitis severity. Ordinal logistic regression models were used to determine the association. Ordinal regression analyses revealed a significant association between higher adherence to the DASH diet/Mediterranean diet and lower odds to be affected by periodontal diseases in an unadjusted model (OR: 0.92; 95% CI: 0.87, 0.97;
Guarda su PubMed
-
Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment-A Pilot Study.
Nutrients2021 Nov;13(11):. doi: 4165.
Bro? Jan, Campbell Matthew D, Urbanová Jana, Nunes Marisa A, Brunerová Ludmila, Raheli? Dario, Janí?ková ??árská Denisa, Taniwall Arian, Brabec Marek, Berka Vojt?ch, Michalec Juraj, Polák Jan,
Abstract
The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min (minimum: 0.07, maximum: 0.17 mmol/L·min). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min (minimum: 0.06, maximum: 0.19 mmol/L·min). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.
Guarda su PubMed
-
Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.
Nutrients2021 Nov;13(11):. doi: 4164.
Nounu Aayah, Richmond Rebecca C, Stewart Isobel D, Surendran Praveen, Wareham Nicholas J, Butterworth Adam, Weinstein Stephanie J, Albanes Demetrius, Baron John A, Hopper John L, Figueiredo Jane C, Newcomb Polly A, Lindor Noralane M, Casey Graham, Platz Elizabeth A, Marchand Loïc Le, Ulrich Cornelia M, Li Christopher I, van Dujinhoven Fränzel J B, Gsur Andrea, Campbell Peter T, Moreno Víctor, Vodicka Pavel, Vodickova Ludmila, Amitay Efrat, Alwers Elizabeth, Chang-Claude Jenny, Sakoda Lori C, Slattery Martha L, Schoen Robert E, Gunter Marc J, Castellví-Bel Sergi, Kim Hyeong-Rok, Kweon Sun-Seog, Chan Andrew T, Li Li, Zheng Wei, Bishop D Timothy, Buchanan Daniel D, Giles Graham G, Gruber Stephen B, Rennert Gad, Stadler Zsofia K, Harrison Tabitha A, Lin Yi, Keku Temitope O, Woods Michael O, Schafmayer Clemens, Van Guelpen Bethany, Gallinger Steven, Hampel Heather, Berndt Sonja I, Pharoah Paul D P, Lindblom Annika, Wolk Alicja, Wu Anna H, White Emily, Peters Ulrike, Drew David A, Scherer Dominique, Bermejo Justo Lorenzo, Brenner Hermann, Hoffmeister Michael, Williams Ann C, Relton Caroline L,
Abstract
Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a Mendelian randomization (MR) approach, we aimed to address whether levels of SA affected CRC risk, stratifying by aspirin use. A two-sample MR analysis was performed using GWAS summary statistics of SA (INTERVAL and EPIC-Norfolk, N = 14,149) and CRC (CCFR, CORECT, GECCO and UK Biobank, 55,168 cases and 65,160 controls). The DACHS study (4410 cases and 3441 controls) was used for replication and stratification of aspirin-use. SNPs proxying SA were selected via three methods: (1) functional SNPs that influence the activity of aspirin-metabolising enzymes; (2) pathway SNPs present in enzymes' coding regions; and (3) genome-wide significant SNPs. We found no association between functional SNPs and SA levels. The pathway and genome-wide SNPs showed no association between SA and CRC risk (OR: 1.03, 95% CI: 0.84-1.27 and OR: 1.08, 95% CI: 0.86-1.34, respectively). Results remained unchanged upon aspirin use stratification. We found little evidence to suggest that an SD increase in genetically predicted SA protects against CRC risk in the general population and upon stratification by aspirin use.
Guarda su PubMed
-
Which Microbes Like My Diet and What Does It Mean for My Heart?
Nutrients2021 Nov;13(11):. doi: 4146.
Sawicka-?miarowska Emilia, Moniuszko-Malinowska Anna, Kami?ski Karol Adam,
Abstract
Cardiovascular diseases are the most common causes of hospitalization, death and disability in Europe. Despite our knowledge of nonmodifiable and modifiable cardiovascular classical risk factors, the morbidity and mortality in this group of diseases remains high, leading to high social and economic costs. Therefore, it is necessary to explore new factors, such as the gut microbiome, that may play a role in many crucial pathological processes related to cardiovascular diseases. Diet is a potentially modifiable cardiovascular risk factor. Fats, proteins, carbohydrates, vitamins and minerals are nutrients that are essential to the proper function of the human body. The style and composition of the human diet has changed over time, evolving from a hunter-gatherer diet to an industrialized and Westernized modern diet that includes processed products. The relationship between the gut microbiome, diet and cardiovascular diseases is complex and still not fully understood. In this review, we discuss, in the context of diet, why particular microbes occur in individuals and how they can influence the host's cardiovascular system in health and disease. We investigate the role of particular microorganisms and changes in the ratio.
Guarda su PubMed
-
The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities.
Nutrients2021 Nov;13(11):. doi: 4127.
Bima Abdulhadi, Eldakhakhny Basmah, Nuwaylati Dina, Alnami Abrar, Ajabnoor Mohammed, Elsamanoudy Ayman,
Abstract
This scoping review aims to clarify the interplay between obesity, vitamin D deficiency, cellular senescence, and obesity-related metabolic consequences, mainly subclinical atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Obesity is a significant global health problem that involves cellular, environmental, behavioral, and genetic elements. The fundamental cause of obesity throughout all life stages is an energy imbalance, and its consequences are countless and, foremost, very common. Obesity has been comprehensively studied in the literature given its association with low serum vitamin D, with many proposed mechanisms linking the two conditions. Moreover, markers of exaggerated cellular senescence have been proven to accumulate in obese individuals. Subclinical atherosclerosis initiates an early stage that ends in serious cardiac events, and obesity, low vitamin D, and senescent cells largely contribute to its associated chronic low-grade inflammation. Furthermore, NAFLD signifies the hepatic manifestation of metabolic syndrome, and studies have highlighted the important role of obesity, vitamin D deficiency, and cellular senescence in its development. Therefore, we outlined the most important mechanisms tying these conditions to one another.
Guarda su PubMed
-
Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure.
Nutrients2021 Nov;13(11):. doi: 3994.
Malinowska-Borowska Jolanta, Kulik Aleksandra, Buczkowska Marta, Ostr?ga Weronika, Stefaniak Apolonia, Piecuch Ma?gorzata, Garbicz Jagoda, Nowak Jolanta Urszula, Tajstra Mateusz, Jankowska Ewa Anita, G?sior Mariusz, Rozentryt Piotr,
Abstract
Low spot urinary creatinine concentration (SUCR) is a marker of muscle wasting and clinical outcome. The risk factors for low SUCR in heart failure (HF) remain poorly understood. We explored the risk factors for low SUCR related to poor outcomes. In 721 HF patients (age: 52.3 ± 11 years, female: 14%, NYHA: 2.7 ± 0.7) SUCR and Dexa body composition scans were performed. BMI prior HF-onset, weight loss, and appendicular muscle mass were obtained. Each patient was classified as malnutrition or normal by GLIM criteria and three other biochemical indices (CONUT, PNI, and GRNI). Sarcopenia index (SI) as creatinine to cystatin C ratio was also calculated. Within 1 year, 80 (11.1%) patients died. In ROC curve we identified a SUCR value of 0.628 g/L as optimally discriminating surviving from dead. In low SUCR group more advanced HF, higher weight loss and catabolic components of weight trajectory (CCWT), more frequent under-nutrition by GLIM, and lower SI were observed. In multivariate analysis the independent predictors of low SUCR were SI, CCWT, and GNRI score. In conclusion: the risk of low SUCR was associated with a worse outcome. Low SUCR was associated with greater catabolism and sarcopenia but not with biochemical indices of malnutrition.
Guarda su PubMed
