Pubblicazioni - Foti Dott.ssa Grazia

• Left ventricular ejection fraction overcrossing 35% after one year of cardiac resynchronization therapy predicts long term survival and freedom from sudden cardiac death: single center observational experience.
  Int J Cardiol

  2014 Mar;172(1):64-71. doi: 10.1016/j.ijcard.2013.12.005.
  
  Frigerio Maria, Lunati Maurizio, Pasqualucci Daniele, Vargiu Sara, Foti Grazia, Pedretti Stefano, Vittori Claudia, Cattafi Giuseppe, Magenta Giovanni, Campo Claudia, Bisetti Silvia, Mercuro Giuseppe
  
  Abstract
  
  BACKGROUND:
  Reverse remodeling and increased LVEF after CRT correlate with survival and heart failure hospitalizations, but their relationship with the risk of SCD is unclear. We aimed to evaluate whether exceeding a threshold value of 35% for left ventricular ejection fraction (LVEF) 1 year after cardiac resynchronization therapy (CRT) predicts survival and freedom from sudden cardiac death (SCD).
  
  METHODS:
  330 patients who survived ? 6 months after CRT (males 80%, age 62 ± 11 years) were grouped according to 1-year LVEF ? 35% (Group 1, n=187, 57%) or >35% (Group 2, n=143, 43%). According to changes vs. baseline (reduction of left end-systolic volume [LVESV] ? 10% or increase of LVEF% > 10 units), patients were also classified as echocardiographic (Echo) non-responders (Group A, n=152, 46%) or responders (Group B, n=178, 54%).
  
  RESULTS:
  At baseline, LVESV volume was larger and LVEF was lower in Group 1 vs. Group 2 (p<0.001). After 1 year, echocardiographic improvement was greater in Group 2 vs. Group 1 (p<0.001 for changes in both LVESV and LVEF). Over a median follow-up of 49 months, 47 patients (14%) died, 36 in Group 1 vs. 11 in Group 2 (19% vs. 8%, p=0.004). A significantly higher rate of freedom from all-cause mortality (p=0.002), cardiovascular mortality (p<0.001) and SCD (p<0.001) was observed in Group 2. Multivariate analysis demonstrated that only 1-year LVEF >35% was associated with freedom from SCD/VF.
  
  CONCLUSIONS:
  LVEF >35% after 1 year of CRT characterizes a favorable long-term outcome, with a very low risk for SCD.
  
  Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
  
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• Sjögren's syndrome associated with antiphospholipid syndrome and fetal myocardial echogenicity: case report.
  J Prenat Med

  2013 Apr;7(2):29-31.
  
  Giacobbe Annamaria, Grasso Roberta, Foti Grazia, Interdonato Maria Lieta, Mancuso Alfredo
  
  Abstract
  
  INTRODUCTION:
  Sjögren's syndrome is a rare systemic autoimmune disorder associated with pregnancy (0.3-0.6%). The typical occurrence of anti-Ro/SSA and anti-La/SSB autoantibodies in the maternal serum can modify the perinatal outcome: neonatal lupus and congenital heart block are the most common fetal complications.
  
  CASE:
  we report a case of pregnancy complicated by a secondary form of SS associated with antiphospholipid syndrome and fetal myocardial echogenicity.
  
  CONCLUSION:
  in conclusion, increased attention must be paid to pregnancies associated with autoimmune disorders, since careful ultrasonographic and clinical monitoring and preventive treatment with corticosteroids could minimize severe and common fetal complications.
  
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• [What's essential, what's useful and what's superfluous in patients with dilated cardiomyopathy].
  Ital Heart J

  2005 May;6 Suppl 2():28S-34S.
  
  Frigerio Maria, Garascia Andrea, Foti Grazia, Masciocco Gabriella, Distefano Giada, Roubina Elena, Resta Davide
  
  
  
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